|
Virus Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Additionally, tumors grown in nude mice from the CT-26 cells whose Tβ4 expression already been downregulated by virus infection were also drastically reduced.
|
25124811 |
2014 |
|
Ventricular Septal Defects
|
0.010 |
Biomarker
|
group |
BEFREE |
ALDOB and Tβ4 might be potential biomarkers applied for identifying VSD in the further works.
|
31070245 |
2019 |
|
Vascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Delineati+ng the molecular pathways impacted by Tβ4 to promote vascular growth and remodeling may reveal novel targets for prevention and treatment of vascular disease.
|
30063849 |
2018 |
|
Urothelial Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Evaluation of thymosin β4 in the regulation of epithelial-mesenchymal transformation in urothelial carcinoma.
|
20864366 |
2012 |
|
Ureteral obstruction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Compared to the UUO group, Tβ4 treatment decreased the 24-h proteinuria (P < 0.001) and reduced the area of pathological change (P < 0.01); this effect was more apparent in the UUO + high-dose Tβ4 group.
|
29047363 |
2017 |
|
Tumor Progression
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
To test the hypothesis that overexpression of this G-actin sequestering peptide also promotes tumor invasion, we examined not only the invasion capability of Tbeta-4-overexpressing SW480 cells, but also the expression levels of Tbeta-4 as well as several proteins that participate in different stages of tumor progression in matched samples of human primary colorectal adenocarcinoma and liver metastases from several patients.
|
15235586 |
2004 |
|
Tumor Progression
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
On the basis of these data, the process of epithelial-mesenchymal transition could represent the unifying process that explains the role of Tβ4 during fetal development and in cancer progression.
|
23045970 |
2012 |
|
Tumor Progression
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, the TGFβ/Tβ4/MRTF/SRF pathway is critical for metastasis and tumor progression.<b>Implications:</b> These findings define a molecular mechanism underlying a tumor-promoting function of thymosin β4 through activation of MRTF/SRF signaling.<i></i>.
|
29330296 |
2018 |
|
Tumor Progression
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
The genes for PFN1 and TMSB4 are both highly expressed in oral tissue and both encode actin monomer binding proteins thought to play a role in cell motility and possibly other crucial parts of tumor progression.
|
27862305 |
2017 |
|
Tumor Progression
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of Tβ4 was found to be related with predictive characteristics for tumor progression and adverse prognosis.
|
28756979 |
2017 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The preferential expression of the peptide and the increase in intensity of the immunostaining at the invasion front suggests a possible link between the peptide and the process of epithelial mesenchymal transition, suggesting a role for Tβ(4) in colorectal cancer invasion and metastasis.
|
22233609 |
2012 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
To test the hypothesis that overexpression of this G-actin sequestering peptide also promotes tumor invasion, we examined not only the invasion capability of Tbeta-4-overexpressing SW480 cells, but also the expression levels of Tbeta-4 as well as several proteins that participate in different stages of tumor progression in matched samples of human primary colorectal adenocarcinoma and liver metastases from several patients.
|
15235586 |
2004 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Thymosin beta 4 gene silencing in LNT-229 and U87MG glioma cells inhibited migration and invasion, promoted starvation-induced cell death in vitro and enhanced survival of glioma-bearing mice.
|
24355709 |
2014 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that Tβ4 is an important regulator of the ILK/AKT/β-catenin/Integrin signaling cascade to induce cell invasion and migration in colorectal cancer cells, and is a potential target for cancer treatment.
|
25218472 |
2014 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Silencing of TMSB4X expression in HNSCC cell line reduced the proliferation and invasion ability in vitro, as well as inhibited the cervical lymph node metastasis in vivo.
|
28831179 |
2017 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Tβ4 gene silencing in A549 and H1299 cells inhibited cell proliferation, migration, and invasion in vitro and decreased tumor growth in vivo Mechanistic investigations revealed a significant decrease in Notch1 activation in Tβ4 gene-silenced cells.
|
27521796 |
2016 |
|
Squamous cell carcinoma of the head and neck
|
0.010 |
Biomarker
|
disease |
BEFREE |
TMSB4X may be a potential therapeutic target for treating HNSCC patients.
|
28831179 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thymosin β4 was highly expressed in the hepatic cells in the normal adult liver, duct, and acinar cells in pancreas, and muscle cells in the heart and also expressed highly in certain tumor cells, including osteosarcoma, colon adenocarcinoma, esophageal squamous cell carcinoma, kidney and urinary bladder transitional carcinoma, lung cancer, and liver cancer.
|
20975530 |
2011 |
|
Severe Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The data indicate a preventive role of Tβ4 in septic hypercirculation and highlight Tβ4 as a potential therapeutic target in severe sepsis.
|
25604254 |
2015 |
|
Septicemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, we analyzed whether treatment with Tβ4 is able to reduce the pericytes loss in lipopolysaccharides (LPS)-induced sepsis and to improve the hemodynamic function and survival in C57BL/6 mice.
|
25604254 |
2015 |
|
Septicemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Given that Thymosin Beta 4 inhibits the polymerization of F-actin, it is possible that Thymosin Beta 4 decreases mortality in sepsis via the regulation of actin as well as its other anti-inflammatory properties and should be further pursued as a clinical trial in humans with sepsis.
|
29508629 |
2018 |
|
Sepsis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, we analyzed whether treatment with Tβ4 is able to reduce the pericytes loss in lipopolysaccharides (LPS)-induced sepsis and to improve the hemodynamic function and survival in C57BL/6 mice.
|
25604254 |
2015 |
|
Sepsis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Given that Thymosin Beta 4 inhibits the polymerization of F-actin, it is possible that Thymosin Beta 4 decreases mortality in sepsis via the regulation of actin as well as its other anti-inflammatory properties and should be further pursued as a clinical trial in humans with sepsis.
|
29508629 |
2018 |
|
Secondary Neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Thymosin beta 4 (T beta 4) has been shown to be associated with tumor metastasis and angiogenesis; however, its role in pancreatic cancer has not been understood.
|
18094619 |
2008 |
|
Secondary Neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Thymosin β(4) (Tβ(4)) overexpression increases cell migration and tumor metastasis.
|
21621326 |
2011 |